Candesartan cilexetil

Research use only, not for human use.

An angiotensin II receptor antagonist used mainly for the treatment of hypertension.

An angiotensin II receptor antagonist used mainly for the treatment of hypertension.Hypertension Approved.

Cell Viability AssayCell Line:HUVEC cells, HEK293T cells Concentration:0.1 μM, 1 μM, 5 μM, 10 μM Incubation Time:24 h Result:Showed a dose-dependent antiviral effect in ZIKV-infected HUVEC and HEK293T cells.

Animal Model:Dahl salt-sensitive hypertensive ratsDosage:5 mg/kgAdministration:Oral gavage (p.o.)Result:Increased body weight and decreased left ventricular end-diastolic diameter.Decreased the level of iNOS mRNA and ADM mRNA in the left ventricle (LV).Increased the eNOS protein mass in the LV and decreased the immunoreactive ADM contents of LV.Enhanced immunoreactivity for eNOS.Significantly decreased the degree of perivascular fibrosis.Animal Model:Skin wound model rat Dosage:1 mg/kg, 10 mg/kg Administration:Oral Result:Showed 100% re-epithelization of the wound at 1 mg/kg.Significantly suppressed angiogenesis at 10 mg/kg.

TCV-116

GPCR/G Protein

Angiotensin Receptor

angiotensinIIreceptor

Cardiovascular Disease

Hypertension

145040-37-5

610.6597

C33H34N6O6

>98% (HPLC)

DMSO：≥ 50 mg/mL

O=C(OC(C)OC(C1=CC=CC2=C1N(CC3=CC=C(C4=C(C5=NN=NN5)C=CC=C4)C=C3)C(OCC)=N2)=O)OC6CCCCC6

1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester

(-20℃)

With Ice Pack

≥ 2 years